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SODIUM BISULPHITE AR
SODIUM BISULPHITE AR
Sodium bisulfite has been used externally for parasitic skin diseases and as gastrointestinal antiseptic. Sodium hydrogensulfite is an inorganic sodium salt having hydrogensulfite as the counterion. It has a role as a mutagen and an allergen. It is an inorganic sodium salt and a sulfite salt.
Sodium bisulfite (NaHSO3) has been used as a reagent to compose the immunoprecipitation (IP) buffer to chemically modify DNA and to synthesize arsenolipids (AsL). It can also be used as a reagent during the synthesis of 5,6-dihydrouracil-6-sulfonate.
In this work we report the successful use of sodium bisulfite as catalyst for the synthesis of 19 benzothiazoles (BZTs) under microwave irradiation with yields from 80% to 100%. BZT-15 was the most active jack bean urease inhibitor exhibiting a mechanism of action typically of a mixed inhibitor. Its affinity to bind urease active site is 3-fold higher than that to bind allosteric site(s). The BZTs 2, 8–10, 15 and 16 are described for the first time as soil ureases inhibitors.